La sperimentazione
Tutte le nostre principali pubblicazioni
Human Fetal Neural Stem Cells for Neurodegenerative Disease Treatment.
Ferrari D, Gelati M, Profico DC, Vescovi AL
Results Probl Cell Differ. 2018;66:307-329. doi: 10.1007/978-3-319-93485-3_14.
Advances in stem cell therapy for amyotrophic lateral sclerosis
Mazzini L, Ferrari D, Andjus PR, Buzanska L, Cantello R, De Marchi F, Gelati M, Giniatullin R, Glover JC, Grilli M, Kozlova EN, Maioli M, Mitrečić D, Pivoriunas A, Sanchez-Pernaute R, Sarnowska A, Vescovi AL
Expert Opin Biol Ther. 2018 Aug;18(8):865-881. doi: 10.1080/14712598.2018.1503248
Elucidating self-assembling peptide aggregation via Morphoscanner: a new tool for protein-protein structural characterization
Saracino GAA, Fontana F, Jekhmane S, Silva JM, Weingarth M, Gelain F
Advanced Science doi: 10.1002/advs.201800471
Feasible stabilization of chondroitinase abc enables reduced astrogliosis in a chronic model of spinal cord injury Raspa A, Bolla E, Cuscona C, Gelain F
CNS Neurosci Ther. 2018 May 31. doi: 10.1111/cns.12984. [Epub ahead of print]
Generation of the induced pluripotent stem cell line CSSi006-A (3681) from a patient affected by advanced-stage Juvenile Onset Huntington's Disease
Rotundo G, Bidollari E, Ferrari D, Spasari I, Bernardini L, Consoli F, De Luca A, Santimone I, Lamorte G, Migliore S, Squitieri F, Vescovi AL, Rosati J
Stem Cell Res. 2018 Apr 21;29:174-178. doi: 10.1016/j.scr.2018.04.008.
Generation of induced pluripotent stem cell line, CSSi004-A (2962), from a patient diagnosed with Huntington's disease at the presymptomatic stage
Bidollari E, Rotundo G, Ferrari D, Candido O, Bernardini L, Consoli F, De Luca A, Santimone I, Lamorte G, Ilari A, Squitieri F, Vescovi AL, Rosati J.
Stem Cell Res. 2018 Apr;28:145-148. doi: 10.1016/j.scr.2018.02.014. Epub 2018 Feb 21
Production and characterization of CSSI003 (2961) human induced pluripotent stem cells (iPSCs) carrying a novel puntiform mutation in RAI1 gene, Causative of Smith–Magenis syndrome
Altieri F, Turco EM, Vinci E, Torres B, Ferrari D, De Jaco A, Mazzoccoli G, Lamorte G, Nardone A, Della Monica M, Bernardini L, Vescovi AL, Rosati J.
Stem Cell Res. 2018 Apr;28:153-156. doi: 10.1016/j.scr.2018.02.016. Epub 2018 Feb 21.
Production and characterization of human induced pluripotent stem cells (iPSCs) from Joubert Syndrome: CSSi001-A (2850).
Rosati J, Altieri F, Tardivo S, Turco EM, Goldoni M, Spasari I, Ferrari D, Bernardini L, Lamorte G, Valente EM, Vescovi AL.
Stem Cell Res. 2018 Mar;27:74-77. doi: 10.1016/j.scr.2018.01.012. Epub 2018 Jan 9.
Toll-like receptor 4 modulation influences human neural stem cell proliferation and differentiation
Grasselli C, Ferrari D, Zalfa C, Soncini M, Mazzoccoli G, Facchini FA, Marongiu L, Granucci F, Copetti M, Vescovi AL, Peri F, De Filippis L.
Cell Death Dis.2018 Feb 15;9(3):280. doi: 10.1038/s41419-017-0139-8.
Generation of induced pluripotent stem cell line, CSSi002-A (2851), from a patient with juvenile Huntington Disease.
Rosati J, Bidollari E, Rotundo G, Ferrari D, Torres B, Bernardini L, Consoli F, De Luca A, Santimone I, Lamorte G, Squitieri F, Vescovi AL
Stem Cell Res. 2018 Jan 9;27:86-89. doi: 10.1016/j.scr.2018.01.011.
Branched peptides integrate into self-assembled nanostructures and enhance biomechanics of peptidic hydrogels
Pugliese R, Fontana F, Marchini A, Gelain F.
Acta Biomater. 2018 Jan 15;66:258-271. doi: 10.1016/j.actbio.2017.11.026. Epub 2017 Nov 8
Decreased Rhes mRNA levels in the brain of patients with Parkinson's disease and MPTP-treated macaques.
Napolitano F, Booth Warren E, Migliarini S, Punzo D, Errico F, Li Q, Thiolat ML, Vescovi AL, Calabresi P, Bezard E, Morelli M, Konradi C, Pasqualetti M, Usiello A.
PLoS One. 2017 Jul 25;12(7):e0181677. doi: 10.1371/journal.pone.0181677. eCollection 2017
Extracellular vesicles are independent metabolic units with asparaginase activity
Iraci N, Gaude E, Leonardi T, Costa ASH, Cossetti C, Peruzzotti-Jametti L, Bernstock JD, Saini HK, Gelati M, Vescovi AL, Bastos C, Faria N, Occhipinti LG, Enright AJ, Frezza C, Pluchino S.
Nat Chem Biol. 2017 Sep;13(9):951-955. doi: 10.1038/nchembio.2422. Epub 2017 Jul 3.
bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal/astroglial) EGF-generated CNS progenitor cells.
Vescovi AL, Reynolds BA, Fraser DD, Weiss S. Neuron. 1993 Nov;11(5):951-66
Basic fibroblast growth factor supports the proliferation of epidermal growth factor-generated neuronal precursor cells of the adult mouse CNS.
Gritti A, Cova L, Parati EA, Galli R, Vescovi AL. Neurosci Lett. 1995 Feb 13;185(3):151-4.
Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor.
Gritti A, Parati EA, Cova L, Frolichsthal P, Galli R, Wanke E, Faravelli L, Morassutti DJ, Roisen F, Nickel DD, Vescovi AL. J Neurosci. 1996 Feb 1;16(3):1091-10
Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo.
Bjornson CR, Rietze RL, Reynolds BA, Magli MC, Vescovi AL. Science. 1999 Jan 22;283(5401):534-7.
Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation.
Vescovi AL, Parati EA, Gritti A, Poulin P, Ferrario M, Wanke E, Frölichsthal-Schoeller P, Cova L, Arcellana-Panlilio M, Colombo A, Galli R. Exp Neurol. 1999 Mar;156(1):71-83.
Epidermal and fibroblast growth factors behave as mitogenic regulators for a single multipotent stem cell-like population from the subventricular region of the adult mouse forebrain.
Gritti A, Frölichsthal-Schoeller P, Galli R, Parati EA, Cova L, Pagano SF, Bjornson CR, Vescovi AL. J Neurosci. 1999 May 1;19(9):3287-
Establishment and properties of neural stem cell clones: plasticity in vitro and in vivo.
Vescovi AL, Snyder EY. Brain Pathol. 1999 Jul;9(3):569-98. Review
Lineage restriction of neuroepithelial precursor cells from fetal human spinal cord.
Quinn SM, Walters WM, Vescovi AL, Whittemore SR. J Neurosci Res. 1999 Sep 1;57(5):590-602.
Isolation and intracerebral grafting of nontransformed multipotential embryonic human CNS stem cells.
Vescovi AL, Gritti A, Galli R, Parati EA. J Neurotrauma. 1999 Aug;16(8):689-93
Regulation of neuronal differentiation in human CNS stem cell progeny by leukemia inhibitory factor.
Galli R, Pagano SF, Gritti A, Vescovi AL. Dev Neurosci. 2000;22(1-2):86-95.
Establishment and properties of a growth factor-dependent, perpetual neural stem cell line from the human CNS.
Villa A, Snyder EY, Vescovi A, Martínez-Serrano A. Exp Neurol. 2000 Jan;161(1):67-84.
The possibilities/perplexities of stem cells.
Snyder EY, Vescovi AL. Nat Biotechnol. 2000 Aug;18(8):827-8. No abstract available
The neural stem cells and their transdifferentiation capacity.
Vescovi AL, Galli R, Gritti A. Biomed Pharmacother. 2001 May;55(4):201-5. Review.
Adult neural stem cells: plasticity and developmental potential.
Gritti A, Vescovi AL, Galli R. J Physiol Paris. 2002 Jan-Mar;96(1-2):81-90. Review.
Clonal analyses and cryopreservation of neural stem cell cultures.
Vescovi AL, Galli R, Gritti A. Methods Mol Biol. 2002;198:115-23. No abstract available.
Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis.
Pluchino S, Quattrini A, Brambilla E, Gritti A, Salani G, Dina G, Galli R, Del Carro U, Amadio S, Bergami A, Furlan R, Comi G, Vescovi AL, Martino G. Nature. 2003 Apr 17;422(6933):688-94.
Neural stem cells: an overview.
Galli R, Gritti A, Bonfanti L, Vescovi AL. Circ Res. 2003 Apr 4;92(6):598-608. Review.
The stem cells as a potential treatment for neurodegeneration.
Daniela F, Vescovi AL, Bottai D. Methods Mol Biol. 2007;399:199-213. doi: 10.1007/978-1-59745-504-6_14. Review
Adult neural stem cells.
Galli R, Gritti A, Vescovi AL. Methods Mol Biol. 2008;438:67-84. doi: 10.1007/978-1-59745-133-8_7.
Clonal analyses and cryopreservation of neural stem cell cultures.
Gritti A, Galli R, Vescovi AL. Methods Mol Biol. 2008;438:173-84. doi: 10.1007/978-1-59745-133-8_1
Multipotential neural precursors transplanted into the metachromatic leukodystrophy brain fail to generate oligodendrocytes but contribute to limit brain dysfunction.
Givogri MI, Bottai D, Zhu HL, Fasano S, Lamorte G, Brambilla R, Vescovi A, Wrabetz L, Bongarzone E. Dev Neurosci. 2008;30(5):340-57. doi: 10.1159/000150127. Epub 2008 Jul 30. Erratum in: Dev Neurosci. 2008;30(5):357.
The role of animal models in evaluating reasonable safety and efficacy for human trials of cell-based interventions for neurologic conditions.
Regenberg A, Mathews DJ, Blass DM, Bok H, Coyle JT, Duggan P, Faden R, Finkel J, Gearhart JD, Hillis A, Hoke A, Johnson R, Johnston M, Kahn J, Kerr D, King P, Kurtzberg J, Liao SM, McDonald JW, McKhann G, Nelson KB, Rao M, Siegel AW, Smith K, Solter D, Song H, Sugarman J, Vescovi A, Young W, Greely HT, Traystman RJ. J Cereb Blood Flow Metab. 2009 Jan;29(1):1-9. doi: 10.1038/jcbfm.2008.98. Epub 2008 Aug 27. Review.
Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates.
Pluchino S, Gritti A, Blezer E, Amadio S, Brambilla E, Borsellino G, Cossetti C, Del Carro U, Comi G, ‘t Hart B, Vescovi A, Martino G. Ann Neurol. 2009 Sep;66(3):343-54. doi: 10.1002/ana.21745.
GFAPdelta in radial glia and subventricular zone progenitors in the developing human cortex.
Middeldorp J, Boer K, Sluijs JA, De Filippis L, Encha-Razavi F, Vescovi AL, Swaab DF, Aronica E, Hol EM. Development. 2010 Jan;137(2):313-21. doi: 10.1242/dev.041632.
Mild hypoxia enhances proliferation and multipotency of human neural stem cells.
Santilli G, Lamorte G, Carlessi L, Ferrari D, Rota Nodari L, Binda E, Delia D, Vescovi AL, De Filippis L. PLoS One. 2010 Jan 5;5(1):e8575. doi: 10.1371/journal.pone.000857
Robust generation of oligodendrocyte progenitors from human neural stem cells and engraftment in experimental demyelination models in mice.
Neri M, Maderna C, Ferrari D, Cavazzin C, Vescovi AL, Gritti A. PLoS One. 2010 Apr 12;5(4):e10145. doi: 10.1371/journal.pone.0010145.
Isolation of neural stem cells from neural tissues using the neurosphere technique.
Ferrari D, Binda E, De Filippis L, Vescovi AL. Curr Protoc Stem Cell Biol. 2010 Nov;Chapter 2:Unit2D.6. doi: 10.1002/9780470151808.sc02d06s15
Transplantation of nanostructured composite scaffolds neuro-prosthetics results in tissue reconstruction, axonal regeneration and neurological recovery in the chronically injured rat spinal cord
Gelain F, Panseri S, Antonini S, Cunha C, Donega M, Lowery J, Taraballi F, Cerri G, Montagna M, Baldissera F, Vescovi A . – ACS Nano 2011 Jan 25;5(1):227-36. doi: 10.1021/nn102461w. Epub 2010 Dec 28
BMHP1-derived self-assembling peptides: hierarchically assembled structures with self-healing propensity and potential for tissue engineering applications
Gelain F, Silva D, Caprini A, Villa O, Taraballi F, Natalello A, Nam KT, Doglia SM, Vescovi A – ACS Nano 2011 Mar 22;5(3):1845-59. doi: 10.1021/nn102663a. Epub 2011 Feb 11.
Evaluation of Early and Late Effects into the Acute Spinal Cord Injury of an Injectable Functionalized Self-assembling Scaffold
Cigognini D, Satta A, Colleoni B, Silva D, Donega’ M, Antonini S, Gelain F – PLoS ONE 2011;6(5):e19782. doi: 10.1371/journal.pone.0019782. Epub 2011 May 18.
Differential pathotropism of non-immortalized and immortalized human neural stem cell lines in a focal demyelination model.
Ferrari D, Zalfa C, Nodari LR, Gelati M, Carlessi L, Delia D, Vescovi AL, De Filippis L. Cell Mol Life Sci. 2012 Apr;69(7):1193-210. doi: 10.1007/s00018-011-0873-5. Epub 2011 Nov 11
Long-term survival of human neural stem cells in the ischemic rat brain upon transient immunosuppression.
Franchi S, Valsecchi AE, Borsani E, Procacci P, Ferrari D, Zalfa C, Sartori P, Rodella LF, Vescovi A, Maione S, Rossi F, Sacerdote P, Colleoni M, Panerai AE. Pain. 2012 Apr;153(4):850-61. doi: 10.1016/j.pain.2012.01.008. Epub 2012 Feb 8. Erratum in: Pain. 2012 Aug;153(8):1775. Zaffa, Cristina [corrected to Zalfa, Cristina].
New Bioactive Motifs and Their Use in Functionalized Self-Assembling Peptides for NSC Differentiation and Neural Tissue Engineering
Gelain F, Cigognini D, Caprini A, Silva D, Colleoni B, Donegá B, Antonini S, Cohen BE, Vescovi A. – Nanoscale 4(9):2946-2957 Nanoscale 2012 Apr 28;4(9):2946-57. doi: 10.1039/c2nr30220a. Epub 2012 Apr 4.
Intravenous neural stem cells abolish nociceptive hypersensitivity and trigger nerve regeneration in experimental neuropathy.
Franchi S, Valsecchi AE, Borsani E, Procacci P, Ferrari D, Zalfa C, Sartori P, Rodella LF, Vescovi A, Maione S, Rossi F, Sacerdote P, Colleoni M, Panerai AE. Pain. 2012 Apr;153(4):850-61. doi: 10.1016/j.pain.2012.01.008. Epub 2012 Feb 8. Erratum in: Pain. 2012 Aug;153(8):1775. Zaffa, Cristina [corrected to Zalfa, Cristina].
Nanomaterials design and tests for neural tissue engineering
Saracino GAA, Cigognini D, Silva D, Caprini A, Gelain F – Chemical Society Reviews 42(1):225-262 -January 2013
Synthesis and Characterization of Designed BMHP1-Derived Self-Assembling Peptides for tissue engineering applications
Silva D, Natalello A, Sanii B, Vasita R, Saracino GAA, Zuckermann RN, Doglia SM, Gelain F – Nanoscale 5(2):704-718.
Modeling and analysis of early aggregation events of BMHP1-derived self-assembling peptides
Saracino G and Gelain F – Journal of Biomolecular Structure & Dynamics 32(5): 759-775.
A Novel Bioactive Peptide: Assessing its Activity Over Murine Neural Stem Cells and its Potential for Neural Tissue Engineering
Caprini A, Silva D, Zanoni I, Cunha C, Volontè C, Vescovi A, Gelain F – New Biotechnology 30(5): 552-562 – N Biotechnol. 2013 Jun 25;30(5):552-62. doi: 10.1016/j.nbt.2013.03.005. Epub 2013 Mar 26.
Culturing and expansion of "clinical grade" precursors cells from the fetal human central nervous system.
Gelati M, Profico D, Projetti-Pensi M, Muzi G, Sgaravizzi G, Vescovi AL. Methods Mol Biol. 2013;1059:65-77. doi: 10.1007/978-1-62703-574-3_
Evaluation of mechanical properties and therapeutic effect of injectable self-assembling hydrogels for spinal cord injury.
Cigognini D, Silva D, Paloppi S, Gelain F – Journal of Biomedical Nanotechnology 10: 309-323.
Complementary Co-Assembling Peptides: from in silico studies to in vivo application
Raspa A, Saracino G, Pugliese R, Silva D, Cigognini D, Vescovi A, Gelain F. – Advanced Functional Materials 40(24): 6317-6328. doi: 10.1002/adfm.201400956
Adult stem cell as new advanced therapy for experimental neuropathic pain treatment.
Franchi S, Castelli M, Amodeo G, Niada S, Ferrari D, Vescovi A, Brini AT, Panerai AE, Sacerdote P. Biomed Res Int. 2014;2014:470983. doi: 10.1155/2014/470983. Epub 2014 Aug 13. Review.
Human neural stem cell transplantation in ALS: initial results from a phase I trial.
Mazzini L, Gelati M, Profico DC, Sgaravizzi G, Projetti Pensi M, Muzi G, Ricciolini C, Rota Nodari L, Carletti S, Giorgi C, Spera C, Domenico F, Bersano E, Petruzzelli F, Cisari C, Maglione A, Sarnelli MF, Stecco A, Querin G, Masiero S, Cantello R, Ferrari D, Zalfa C, Binda E, Visioli A, Trombetta D, Novelli A, Torres B, Bernardini L, Carriero A, Prandi P, Servo S, Cerino A, Cima V, Gaiani A, Nasuelli N, Massara M, Glass J, Sorarù G, Boulis NM, Vescovi AL. J Transl Med. 2015 Jan 27;13:17. doi: 10.1186/s12967-014-0371-2.
The Big Bluff of Amyotrophic Lateral Sclerosis Diagnosis: The Role of Neurodegenerative Disease Mimics.
Bicchi I, Emiliani C, Vescovi A, Martino S. Neurodegener Dis. 2015;15(6):313-21. doi: 10.1159/000435917. Epub 2015 Jul 30
Stem cells therapy for ALS.
Mazzini L, Vescovi A, Cantello R, Gelati M, Vercelli A. Expert Opin Biol Ther. 2015 Nov 11. [Epub ahead of print]
Recent therapeutic approaches for spinal cord injury
Raspa A, Pugliese R, Maleki M, Gelain F. – Biotechnology & Bioengineering 113(2): 253-259. doi: 10.1002/bit.25689.
A biocompatibility study of new nanofibrous scaffolds for nervous system regeneration.
Raspa A., Marchini A., Pugliese R., Mauri M., Maleki M., Vasita R., Gelain F. – Epub 2016 Jan 9.
Glial degeneration with oxidative damage drives neuronal demise in MPSII disease
Cristina Zalfa, Chiara Verpelli, Francesca D’Avanzo, Rosella Tomanin, Cinzia Vicidomini, Laura Cajola, Renzo Manara, Carlo Sala, Maurizio Scarpa, Angelo Luigi Vescovi, Lidia De Filippis
Peptidic biomaterials: from self-assembling to regenerative medicine
Pugliese R. and Gelain F. – Trends in Biotechnology. doi: 10.1016/j.tibtech.2016.09.004
Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials?
A cura di: Atassi N., Beghi E., Blanquer M., Boulis NM., Cantello R., Caponnetto C., Chiò A., Dunnett SB., Feldman EL., Vescovi A., Mazzini L. – Collaboratori: Bendotti C., Bersano E., Brajkovic S., Car P., De Marchi F., Fantozzi R., Follenzi A., Gelati M., Giorgi C., Grilli M., Guenzi P., La Bella V., Mancardi GL., Panzarasa G., Poloni M., Profico D., Silani V., Sorarù G., Spataro R., Stecco A., Vercelli A. – Cytotherapy , 6 Ottobre 2016
