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Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor.

Gritti A, Parati EA, Cova L, Frolichsthal P, Galli R, Wanke E, Faravelli L, Morassutti DJ, Roisen F, Nickel DD, Vescovi AL. J Neurosci. 1996 Feb 1;16(3):1091-10

Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo.

Bjornson CR, Rietze RL, Reynolds BA, Magli MC, Vescovi AL. Science. 1999 Jan 22;283(5401):534-7.

Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation.

Vescovi AL, Parati EA, Gritti A, Poulin P, Ferrario M, Wanke E, Frölichsthal-Schoeller P, Cova L, Arcellana-Panlilio M, Colombo A, Galli R. Exp Neurol. 1999 Mar;156(1):71-83.

Epidermal and fibroblast growth factors behave as mitogenic regulators for a single multipotent stem cell-like population from the subventricular region of the adult mouse forebrain.

Gritti A, Frölichsthal-Schoeller P, Galli R, Parati EA, Cova L, Pagano SF, Bjornson CR, Vescovi AL. J Neurosci. 1999 May 1;19(9):3287-

Establishment and properties of neural stem cell clones: plasticity in vitro and in vivo.

Vescovi AL, Snyder EY. Brain Pathol. 1999 Jul;9(3):569-98. Review

Lineage restriction of neuroepithelial precursor cells from fetal human spinal cord.

Quinn SM, Walters WM, Vescovi AL, Whittemore SR. J Neurosci Res. 1999 Sep 1;57(5):590-602.

Isolation and intracerebral grafting of nontransformed multipotential embryonic human CNS stem cells.

Vescovi AL, Gritti A, Galli R, Parati EA. J Neurotrauma. 1999 Aug;16(8):689-93

Regulation of neuronal differentiation in human CNS stem cell progeny by leukemia inhibitory factor.

Galli R, Pagano SF, Gritti A, Vescovi AL. Dev Neurosci. 2000;22(1-2):86-95.

Establishment and properties of a growth factor-dependent, perpetual neural stem cell line from the human CNS.

Villa A, Snyder EY, Vescovi A, Martínez-Serrano A. Exp Neurol. 2000 Jan;161(1):67-84.

The possibilities/perplexities of stem cells.

Snyder EY, Vescovi AL. Nat Biotechnol. 2000 Aug;18(8):827-8. No abstract available

The neural stem cells and their transdifferentiation capacity.

Vescovi AL, Galli R, Gritti A. Biomed Pharmacother. 2001 May;55(4):201-5. Review.

Adult neural stem cells: plasticity and developmental potential.

Gritti A, Vescovi AL, Galli R. J Physiol Paris. 2002 Jan-Mar;96(1-2):81-90. Review.

Clonal analyses and cryopreservation of neural stem cell cultures.

Vescovi AL, Galli R, Gritti A. Methods Mol Biol. 2002;198:115-23. No abstract available.

Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis.

Pluchino S, Quattrini A, Brambilla E, Gritti A, Salani G, Dina G, Galli R, Del Carro U, Amadio S, Bergami A, Furlan R, Comi G, Vescovi AL, Martino G. Nature. 2003 Apr 17;422(6933):688-94.

Neural stem cells: an overview.

Galli R, Gritti A, Bonfanti L, Vescovi AL. Circ Res. 2003 Apr 4;92(6):598-608. Review.

The stem cells as a potential treatment for neurodegeneration.

Daniela F, Vescovi AL, Bottai D. Methods Mol Biol. 2007;399:199-213. doi: 10.1007/978-1-59745-504-6_14. Review

Adult neural stem cells.

Galli R, Gritti A, Vescovi AL. Methods Mol Biol. 2008;438:67-84. doi: 10.1007/978-1-59745-133-8_7.

Clonal analyses and cryopreservation of neural stem cell cultures.

Gritti A, Galli R, Vescovi AL. Methods Mol Biol. 2008;438:173-84. doi: 10.1007/978-1-59745-133-8_1

Multipotential neural precursors transplanted into the metachromatic leukodystrophy brain fail to generate oligodendrocytes but contribute to limit brain dysfunction.

Givogri MI, Bottai D, Zhu HL, Fasano S, Lamorte G, Brambilla R, Vescovi A, Wrabetz L, Bongarzone E. Dev Neurosci. 2008;30(5):340-57. doi: 10.1159/000150127. Epub 2008 Jul 30. Erratum in: Dev Neurosci. 2008;30(5):357.

The role of animal models in evaluating reasonable safety and efficacy for human trials of cell-based interventions for neurologic conditions.

Regenberg A, Mathews DJ, Blass DM, Bok H, Coyle JT, Duggan P, Faden R, Finkel J, Gearhart JD, Hillis A, Hoke A, Johnson R, Johnston M, Kahn J, Kerr D, King P, Kurtzberg J, Liao SM, McDonald JW, McKhann G, Nelson KB, Rao M, Siegel AW, Smith K, Solter D, Song H, Sugarman J, Vescovi A, Young W, Greely HT, Traystman RJ. J Cereb Blood Flow Metab. 2009 Jan;29(1):1-9. doi: 10.1038/jcbfm.2008.98. Epub 2008 Aug 27. Review.

Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates.

Pluchino S, Gritti A, Blezer E, Amadio S, Brambilla E, Borsellino G, Cossetti C, Del Carro U, Comi G, ‘t Hart B, Vescovi A, Martino G. Ann Neurol. 2009 Sep;66(3):343-54. doi: 10.1002/ana.21745.

GFAPdelta in radial glia and subventricular zone progenitors in the developing human cortex.

Middeldorp J, Boer K, Sluijs JA, De Filippis L, Encha-Razavi F, Vescovi AL, Swaab DF, Aronica E, Hol EM. Development. 2010 Jan;137(2):313-21. doi: 10.1242/dev.041632.

Mild hypoxia enhances proliferation and multipotency of human neural stem cells.

Santilli G, Lamorte G, Carlessi L, Ferrari D, Rota Nodari L, Binda E, Delia D, Vescovi AL, De Filippis L. PLoS One. 2010 Jan 5;5(1):e8575. doi: 10.1371/journal.pone.000857

Robust generation of oligodendrocyte progenitors from human neural stem cells and engraftment in experimental demyelination models in mice.

Neri M, Maderna C, Ferrari D, Cavazzin C, Vescovi AL, Gritti A. PLoS One. 2010 Apr 12;5(4):e10145. doi: 10.1371/journal.pone.0010145.

Isolation of neural stem cells from neural tissues using the neurosphere technique.

Ferrari D, Binda E, De Filippis L, Vescovi AL. Curr Protoc Stem Cell Biol. 2010 Nov;Chapter 2:Unit2D.6. doi: 10.1002/9780470151808.sc02d06s15

Transplantation of nanostructured composite scaffolds neuro-prosthetics results in tissue reconstruction, axonal regeneration and neurological recovery in the chronically injured rat spinal cord

Gelain F, Panseri S, Antonini S, Cunha C, Donega M, Lowery J, Taraballi F, Cerri G, Montagna M, Baldissera F, Vescovi A . – ACS Nano 2011 Jan 25;5(1):227-36. doi: 10.1021/nn102461w. Epub 2010 Dec 28

BMHP1-derived self-assembling peptides: hierarchically assembled structures with self-healing propensity and potential for tissue engineering applications

Gelain F, Silva D, Caprini A, Villa O, Taraballi F, Natalello A, Nam KT, Doglia SM, Vescovi A – ACS Nano 2011 Mar 22;5(3):1845-59. doi: 10.1021/nn102663a. Epub 2011 Feb 11.

Evaluation of Early and Late Effects into the Acute Spinal Cord Injury of an Injectable Functionalized Self-assembling Scaffold

Cigognini D, Satta A, Colleoni B, Silva D, Donega’ M, Antonini S, Gelain F – PLoS ONE 2011;6(5):e19782. doi: 10.1371/journal.pone.0019782. Epub 2011 May 18.

Differential pathotropism of non-immortalized and immortalized human neural stem cell lines in a focal demyelination model.

Ferrari D, Zalfa C, Nodari LR, Gelati M, Carlessi L, Delia D, Vescovi AL, De Filippis L. Cell Mol Life Sci. 2012 Apr;69(7):1193-210. doi: 10.1007/s00018-011-0873-5. Epub 2011 Nov 11

Long-term survival of human neural stem cells in the ischemic rat brain upon transient immunosuppression.

Franchi S, Valsecchi AE, Borsani E, Procacci P, Ferrari D, Zalfa C, Sartori P, Rodella LF, Vescovi A, Maione S, Rossi F, Sacerdote P, Colleoni M, Panerai AE. Pain. 2012 Apr;153(4):850-61. doi: 10.1016/j.pain.2012.01.008. Epub 2012 Feb 8. Erratum in: Pain. 2012 Aug;153(8):1775. Zaffa, Cristina [corrected to Zalfa, Cristina].

New Bioactive Motifs and Their Use in Functionalized Self-Assembling Peptides for NSC Differentiation and Neural Tissue Engineering

Gelain F, Cigognini D, Caprini A, Silva D, Colleoni B, Donegá B, Antonini S, Cohen BE, Vescovi A. – Nanoscale 4(9):2946-2957 Nanoscale 2012 Apr 28;4(9):2946-57. doi: 10.1039/c2nr30220a. Epub 2012 Apr 4.

Intravenous neural stem cells abolish nociceptive hypersensitivity and trigger nerve regeneration in experimental neuropathy.

Franchi S, Valsecchi AE, Borsani E, Procacci P, Ferrari D, Zalfa C, Sartori P, Rodella LF, Vescovi A, Maione S, Rossi F, Sacerdote P, Colleoni M, Panerai AE. Pain. 2012 Apr;153(4):850-61. doi: 10.1016/j.pain.2012.01.008. Epub 2012 Feb 8. Erratum in: Pain. 2012 Aug;153(8):1775. Zaffa, Cristina [corrected to Zalfa, Cristina].

Nanomaterials design and tests for neural tissue engineering

Saracino GAA, Cigognini D, Silva D, Caprini A, Gelain F – Chemical Society Reviews 42(1):225-262 -January 2013

Synthesis and Characterization of Designed BMHP1-Derived Self-Assembling Peptides for tissue engineering applications

Silva D, Natalello A, Sanii B, Vasita R, Saracino GAA, Zuckermann RN, Doglia SM, Gelain F – Nanoscale 5(2):704-718.

Modeling and analysis of early aggregation events of BMHP1-derived self-assembling peptides

Saracino G and Gelain F – Journal of Biomolecular Structure & Dynamics 32(5): 759-775.

A Novel Bioactive Peptide: Assessing its Activity Over Murine Neural Stem Cells and its Potential for Neural Tissue Engineering

Caprini A, Silva D, Zanoni I, Cunha C, Volontè C, Vescovi A, Gelain F –   New Biotechnology 30(5): 552-562 – N Biotechnol. 2013 Jun 25;30(5):552-62. doi: 10.1016/j.nbt.2013.03.005. Epub 2013 Mar 26.

Culturing and expansion of "clinical grade" precursors cells from the fetal human central nervous system.

Gelati M, Profico D, Projetti-Pensi M, Muzi G, Sgaravizzi G, Vescovi AL. Methods Mol Biol. 2013;1059:65-77. doi: 10.1007/978-1-62703-574-3_

Evaluation of mechanical properties and therapeutic effect of injectable self-assembling hydrogels for spinal cord injury.

Cigognini D, Silva D, Paloppi S, Gelain F – Journal of Biomedical Nanotechnology 10: 309-323.

Complementary Co-Assembling Peptides: from in silico studies to in vivo application

Raspa A, Saracino G, Pugliese R, Silva D, Cigognini D, Vescovi A, Gelain F. – Advanced Functional Materials 40(24): 6317-6328. doi: 10.1002/adfm.201400956

Adult stem cell as new advanced therapy for experimental neuropathic pain treatment.

Franchi S, Castelli M, Amodeo G, Niada S, Ferrari D, Vescovi A, Brini AT, Panerai AE, Sacerdote P. Biomed Res Int. 2014;2014:470983. doi: 10.1155/2014/470983. Epub 2014 Aug 13. Review.

Human neural stem cell transplantation in ALS: initial results from a phase I trial.

Mazzini L, Gelati M, Profico DC, Sgaravizzi G, Projetti Pensi M, Muzi G, Ricciolini C, Rota Nodari L, Carletti S, Giorgi C, Spera C, Domenico F, Bersano E, Petruzzelli F, Cisari C, Maglione A, Sarnelli MF, Stecco A, Querin G, Masiero S, Cantello R, Ferrari D, Zalfa C, Binda E, Visioli A, Trombetta D, Novelli A, Torres B, Bernardini L, Carriero A, Prandi P, Servo S, Cerino A, Cima V, Gaiani A, Nasuelli N, Massara M, Glass J, Sorarù G, Boulis NM, Vescovi AL. J Transl Med. 2015 Jan 27;13:17. doi: 10.1186/s12967-014-0371-2.

The Big Bluff of Amyotrophic Lateral Sclerosis Diagnosis: The Role of Neurodegenerative Disease Mimics.

Bicchi I, Emiliani C, Vescovi A, Martino S. Neurodegener Dis. 2015;15(6):313-21. doi: 10.1159/000435917. Epub 2015 Jul 30

Stem cells therapy for ALS.

Mazzini L, Vescovi A, Cantello R, Gelati M, Vercelli A. Expert Opin Biol Ther. 2015 Nov 11. [Epub ahead of print]

Recent therapeutic approaches for spinal cord injury

Raspa A, Pugliese R, Maleki M, Gelain F. – Biotechnology & Bioengineering 113(2): 253-259. doi: 10.1002/bit.25689.

A biocompatibility study of new nanofibrous scaffolds for nervous system regeneration.

Raspa A., Marchini A., Pugliese R., Mauri M., Maleki M., Vasita R., Gelain F. – Epub 2016 Jan 9.

Glial degeneration with oxidative damage drives neuronal demise in MPSII disease

Cristina Zalfa, Chiara Verpelli, Francesca D’Avanzo, Rosella Tomanin, Cinzia Vicidomini, Laura Cajola, Renzo Manara, Carlo Sala, Maurizio Scarpa, Angelo Luigi Vescovi, Lidia De Filippis

Peptidic biomaterials: from self-assembling to regenerative medicine

Pugliese R. and Gelain F. – Trends in Biotechnology. doi: 10.1016/j.tibtech.2016.09.004

Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials?

A cura di: Atassi N., Beghi E., Blanquer M., Boulis NM., Cantello R., Caponnetto C., Chiò A., Dunnett SB., Feldman EL., Vescovi A., Mazzini L. – Collaboratori: Bendotti C., Bersano E., Brajkovic S., Car P., De Marchi F., Fantozzi R., Follenzi A., Gelati M., Giorgi C., Grilli M., Guenzi P., La Bella V., Mancardi GL., Panzarasa G., Poloni M., Profico D., Silani V., Sorarù G., Spataro R., Stecco A., Vercelli A. – Cytotherapy , 6 Ottobre 2016

Fabrication of nanofibrous electrospun scaffolds from a heterogeneous library of co- and self-assembling peptides”

A cura di Mahboubeh Maleki, Antonino Natalello, Raffaele Pugliese, Fabrizio Gelain
Acta Biomaterialia, 16 January 2017